What does gangrene refer to?

Gangrene specifically refers to the death of tissue that occurs when there is a significant and prolonged loss of blood supply to that tissue. This can happen due to various factors such as infection, injury, or a serious underlying medical condition, which impede the blood flow. When tissues are deprived of blood, they do not receive essential nutrients and oxygen, leading to cell death. This condition is critical because it can lead to serious health complications, including the need for amputation or systemic infection if the dead tissue is not treated promptly.

The other choices do not accurately capture this medical condition. Abnormal hair growth pertains to a different aspect of health and does not involve tissue death. A fluid-filled blister refers to a localized skin condition that does not involve necrosis of tissue. Inflammation of skin cells is another distinct process involving immune response and would not specifically indicate tissue death due to blood supply loss.