Which suffix could indicate a significant medical condition affecting blood?

The suffix "-emia" specifically refers to a condition related to the presence of substances in the blood or alterations in the blood itself. It is commonly used in medical terminology to denote various blood disorders or conditions, such as anemia (a deficiency of red blood cells), leukemia (a type of cancer affecting the blood and bone marrow), and hyperglycemia (elevated glucose levels in the blood). Therefore, when considering significant medical conditions affecting blood, "-emia" is the appropriate suffix as it directly pertains to the blood's composition and related health issues.

The other suffixes provided denote different types of conditions: "-itis" refers to inflammation, which can involve various tissues but is not specifically limited to blood-related conditions; "-megaly" indicates enlargement of an organ, which may or may not relate to blood specifics; and "-rrhagia" signifies excessive bleeding or discharge, focusing on the nature of fluid loss rather than a condition inherently affecting the blood's composition itself.